Tranexamic Acid

Product name : Tranexamic acid

Standard : BP2012

CAS : 1197-18-8

Molecular formula : C8H15NO2

Molecular weight : 157.21

Appearance : A white crystalline powder odorless , slightly bitter taste

Purity: 99%~101% Tranexamic acid

Tranexamic acid is a synthetic derivative of the amino acid lysine.Tranexamic acid (commonly marketed in tablet form as Lysteda and in IV form as Cyklokapron in the U.S. and as Transamin,Transcam in Asia, and Espercil in South America) is often prescribed for excessive bleeding.

Tranexamic acid is an antifibrinolytic that competitively inhibits the activation of plasminogen to plasmin, a molecule responsible for the degradation of fibrin. Fibrin is the basic framework for the formation of a blood clot in hemostasis.Tranexamic acid has roughly 8 times the antifibrinolytic activity of an older analogue, ε-aminocaproic acid.

Usage of Tranexamic Acid:

1.Menstrual bleeding

Tranexamic acid exerts its antifibrinolytic effect through the reversible blockade of lysine-binding sites on plasminogen molecules.Tranexamic acid inhibits endometrial plasminogen activator and thus prevents fibrinolysis and the breakdown of blood clots.

Tranexamic acid is used as firstline nonhormonal treatment of dysfunctional uterine bleeding, and heavy bleeding associated with uterine fibroids. The histological appearance of the necrosis in women treated by tranexamic acid is no different from the spontaneous incidence of thrombosis.

2.Orthopedic Surgery

Tranexamic acid is used in orthopedic surgery to reduce bloodloss. Tranexamic acid is of proven value in clearing the field of surgery and reducing pre- and postoperative blood loss. Drain and number of transfusions are reduced. Tranexamic acid is commonly used in joint replacement surgery.

3.Trauma

Tranexamic acid should be considered for use in bleeding trauma patients.

4.Dentistry

Tranexamic acid is used in dentistry in the form of a 5% mouth rinse after extractions or surgery in patients with prolonged bleeding time, e.g. from acquired or inherited disorders.